PRIMARY ANTIBODY

CD38 (C3G3), MMab

CD38 is a type II transmembrane glycoprotein with a molecular weight of 46 kDa. CD38 is an enzyme with ADP-ribosyl cyclase, cycic ADP-ribose hydrolase, and NAD glycohydrolase activities, and is involved in the formation and hydrolysis of cADPR. cADPR acts as a second messenger to regulate intracellular Ca2+ ion mobilization. Although the CD38 molecule was originally described as a T-lymphocyte differentiation antigen, the CD38 antigen is found in cells and tissues. The CD38 antigen can provide favorable signals for the growth and differentiation of lymphocytes and myeloid cells. During the differentiation process of mature B cells and T cells, it is not found in most mature peripheral lymphocytes. CD38 is also present in thymocytes, pro-B cells, erminal center B cells, mitogen-activatedT cells 18-secreting plasma cells, NK cells, myeloid erythroid and myeloid cells, and brain cells. It has been reported that the CD38 antigen is also expressed in peripheral neurofibromas, is a pathological indicator of Alzheimer's disease, and appears in theper nuclear body and proximal dendrites of neurons.

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CD34(QBEnd/10), MMab

The CD34 antigen is a 110 kDa single-chain transmembrane glycoprotein. The CD34 protein is selectively expressed in human lymphoid and myeloid hematopoietic progenitor cells, and is also expressed in vascular endothelium.

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CD31(C6E5),MMab

The CD31 antigen is a single-chain transmembrane glycoprotein with a molecular weight of 130to 140 kDa. The CD31 molecule is expressed on the surface of platelets, monocytes, granulocytes, B cells and at the intercellular junctions of endothe lial cells. The CD31 molecule has an extracellular domain subclass domains, which is a typical cell-cell adhesion molecule. This containing 6 lg-like homology c2 domain mediates endothe lial cell-cell adhesion and plays a role in maintaining the connection between endothe lial cells and the stability of the endothe lial monolayer. The CD31 molecule also has a cytoplasmic domain that becomes a potential phosphorylation site after cell activation. The properties of the CD31 antigen indicate that it is involved in interations in angiogenesis, thrombosis, and wound healing. Angiogenesis is the basis of tumor growth and metastasis.

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CD31(C12A6),MMab

The CD31 antigen is a single-chain transmembrane glycoprotein with a molecular weight of 130to 140 kDa. The CD31 molecule is expressed on the surface of platelets, monocytes, granulocytes, B cells and at the intercellular junctions of endothe lial cells. The CD31 molecule has an extracellular domainsubclass domains, which is a typical cell-cell adhesion molecule. Thiscontaining 6 lg-like homology c2domain mediates endothe lial cell-cell adhesion and plays a role in maintaining the connection between endothe lial cells and the stability of the endothe lial monolayer. The CD31 molecule also has a cytoplasmic domain that becomes a potential phosphorylation site after cell activation. The properties of the CD31 antigen indicate that it is involved in interations in angiogenesis, thrombosis, and wound healing. Angiogenesis is the basis of tumor growth and metastasis.

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CD30(C5E10),MMab

The CD30 antigen is a receptor for the cytokine ligand CD30L, expressed on the surface of multinucleated Reed-Sternberg cells and most anaplastic large cell lymphomas. The CD30 antigen is also expressed in virus-transformed cells such as EBV-transformed B cells. Most T-cell lymphomas, except for some pleomorphic T-cell lymphomas, do not express the CD30 antigen.

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CD23 (C3B11), MMab

The CD23 molecule is a low-affinity IgE receptor found on B cells. The CD23 antigen is a 45 kDa membrane glycoprotein reported to be present in peripheral blood B cell populations, B Iymphocytes, and EBv-transformed B- lymphoblastoid cell lines. CD23 antigen expression is found in monocytes and dendritic cells.

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CD20(C4A11),MMab

The CD20 antigen is a non-glycosylated phosphoprotein with a molecular weight of approximately 33 kDa, expressed on normal and malignant human B cells, and is thought to act as a receptor in B-cell activation and differentiation. It has been reported that the CD20 antigen is expressed in normal B cells in peripheral blood, lymph nodes, spleen, tonsils, bone marrow, acute leukemias, and chronic lymphocytic leukemias.

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CD15(MMA),MMab

This antibody is mainly present in granulocytes (including neutrophils and eosinophils) and some monocytes. It plays an important role in mediating phagocytosis and chemotaxis. CD15 is often expressed in Reed-Sternberg cells in Hodgkin's lymphoma, especially in classical Hodgkin's lymphoma. Nodular sclerosing Hodgkin's lymphoma is mostly CD15 positive. It is mainly used for the auxiliary diagnosis of Hodgkin's lymphoma and granulocytic sarcoma.

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CD10(C6D1),MMab

The CD10 antigen is widely expressed on the surface of a variety of normal and tumor cells. It has been reported that in other malignant lymphomas, the CD10 antigen is expressed in the cells of lymphoblastic Iymphoma, Burkitt's lymphoma, and follicular lymphoma. The CD10 antigen has been identified on the surface of normal early lymphoblasts, immature cells in adult bone marrow, and germinal center B cells in Iymphoid tissues. The CD10 antigen is also expressed in various non-lymphoid cells and tissues, such as breast myoepithelial cells, fibroblasts, and is particularly highly expressed in the renal brush border and fetal epithelial cells.

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CD8(C2B11),MMab

The CD8 molecule is a 32 kDa glycoprotein composed of two chains, present on the surface of suppressor/cytotoxic Tcells. It is a receptor for MHC class I molecules, and its intracellular part is associated with the p56lck glycoprotein kinase, which regulates the function of the TCR/CD3 complex. This antibody is mainly used to label suppressor/cytotoxic T cells (accounting for about 25-30% of peripheral blood lymphocytes). It is generally used in combination with CD4.

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CD7(C6F3),MMab

CD7 is a 40 kDa membrane-bound protein, the earliest T-lymphocyte-specific antigen expressed, and the only early marker present throughout T-cell differentiation. This antibody can be used to detect normal human T cells and for the classification of lymphomas and leukemias.

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CD7(MRQ-56),MMab

CD7 is a 40 kDa membrane-bound protein, the earliest T-lymphocyte-specific antigen expressed, and the only early marker present throughout T-cell differentiation. This antibody can be used to detect normal human T cells and for the classification of lymphomas and leukemias.

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