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CK5/6/TTF-1 detection reagent (Immunohistochemical)

CK5/6/TTF-1 detection reagent (Immunohistochemical) is mainly used to qualitatively identify TTF-1 and CK5/6 proteins. Using immunohistochemical dual staining detection and multiple antibody combination technology, there are detected two antigen targets at the same time on the same sample tissue section by one staining process.

Product Feature

a) CK5/6 is mainly expressed in the membrane and cytoplasm of squamous epithelial cells and is generally negative in glandular epithelium.

b) CK5/6 is useful for differentiating squamous cell carcinoma from adenocarcinoma.

c) p40 (ΔNp63) is expressed in basal cells of the bronchial mucosa and myoepithelial cells of glands.

d) p40 (ΔNp63) is a sensitive and specific marker for lung squamous cell carcinoma.

e) Combined CK5/6 and p40 staining provides improved sensitivity and specificity for the identification of lung squamous cell carcinoma.

f) When used together with TTF-1 and Napsin A, CK5/6/p40 helps differentiate poorly differentiated lung adenocarcinoma from lung squamous cell carcinoma.